Protein mimetic pupregulated modulator of apoptosis (PUMA ). BH3-only proapoptotic Bcl-family members Noxa and Puma mediate neural precursor cell death. PUMA Dissociates Bax and Bcl-XL to Induce Apoptosis in. The pupregulated modulator of apoptosis (PUMA ) also known as Bcl-2-binding component (BBCis a pro-apoptotic protein, member of the Bcl-protein).
Box : Apoptosis: controlled demolition at the cellular level. PUMA, a potent killer with or without p53. PUMA (pupregulated modulator of apoptosis) is a Bcl-homology (BH3)-only Bcl-family member and a critical mediator of p53-dependent and. BH3-only proapoptotic Bcl-family members Noxa and. Bcl-- , the free encyclopedia Bcl-(B-cell lymphoma encoded in humans by the BCLgene, is the founding member.
NOXA, PUMA and HRK all of which promote apoptosis when overexpressed.
B-cell lymphoma-(BCL-2)-family proteins have a crucial role in the regulation. Genes - Bbc- BCLbinding component OBJECTIVE : Puma (p53-upregulated modulator of apoptosis a proapoptotic BH3-only member of the Bcl-protein family, has been implicated in the).